Yes. OFAC maintains many of its sanctions list files on an FTP server.
This server can be accessed at: ftp://ofacftp.treas.gov.
The server will accept an anonymous login. OFAC's data is stored in the directories listed below. OFAC does not currently support connections to this server via SFTP.
/fac_sdn - SDN human-readable lists, legacy zip archive (XML and delimited files), and the advanced zip archive (advanced XML file)
/fac_delim - SDN data files (advanced XML file, legacy XML file, legacy delimited files) in un archived format
/ssi_list - All Sectoral Sanctions List files
/fse_list - All Foreign Sanctions Evaders List files
/ns_plc - All Non-SDN Palestinian Legislative Council Lists files
/consolidated_list - All Consolidated Non-SDN List data files